DHX36

Across TCGA pan-cancer cohorts, DHX36 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of DHX36’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where DHX36 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types DHX36 is over-expressed in tumor, although a few such as CCRCC show the opposite, repressed pattern.

HNSC, LSCC, and LUAD are the cancer types where DHX36 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DHX36 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.530	<.001	12	view →
LSCC	Male	II,III,IV	+0.811	<.001	9	view →
LUAD	Male	All	+0.293	<.001	9	view →
COAD	Female	III,IV	+0.281	<.001	9	view →
CCRCC	Male	All	−0.083	<.001	6	view →
PDAC	Male	III,IV	+0.192	.027	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

DHX36–HNSC

Open the HNSC breakdown →