DHX36

Across TCGA patient cohorts, DHX36 mutation is significantly associated with the RNA expression of many other genes, with 2,570 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DHX36-associated genes across cancer lineages are ITGB1BP1, PSMB7, and RN7SL342P. Each is linked with DHX36 in more than 2 cancer types. Because this analysis shows association rather than direction, both DHX36-to-partner and partner-to-DHX36 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ITGB1BP1 grouped by DHX36-low versus DHX36-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHX36→partner) and Y-score (partner→DHX36) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ITGB1BP1 →	+0.527	+3.497	<.001	.002	3	3
SKCM	PSMB7 →	+0.429	+3.497	.001	.002	3	3
KIRC	RN7SL342P →	+1.232	+5.377	<.001	.005	3	3
UCEC	CENPU →	+0.517	+2.265	.007	.005	3	3
UCEC	TRAPPC2L →	+0.445	+2.013	<.001	<.001	3	3
UCEC	FEN1 →	+0.601	+3.169	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,570 associations by consensus.

ITGB1BP1 by DHX36 expression — SKCM

Explore this box plot interactively →