DHX36

Across TCGA patient cohorts, DHX36 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DHX36-associated genes across cancer lineages are Caspase-7-cleavedD198, Beclin, and eIF4E. Each is linked with DHX36 in more than 2 cancer types. Because this analysis shows association rather than direction, both DHX36-to-partner and partner-to-DHX36 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by DHX36-low versus DHX36-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHX36→partner) and Y-score (partner→DHX36) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.756	+1.926	<.001	.008	3	3
SKCM	Beclin →	+0.152	+3.169	.041	.017	3	3
UCEC	eIF4E →	+0.180	+3.013	.017	.018	3	2
UCEC	MSH2 →	-0.297	-2.674	<.001	.005	3	2
UCEC	PCNA →	+0.246	+2.584	.001	.010	3	2
UCEC	PEA-15 →	+0.163	+1.925	.016	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Caspase-7-cleavedD198 by DHX36 expression — UCEC

Explore this box plot interactively →