DHX36

Across TCGA cell cohorts, DHX36 mutation is significantly associated with the RNA expression of many other genes, with 421 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DHX36-associated genes across cancer lineages are PRLHR, RGSL1, and LMX1A. Each is linked with DHX36 in more than 1 cancer types. Because this analysis shows association rather than direction, both DHX36-to-partner and partner-to-DHX36 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRLHR grouped by DHX36-low versus DHX36-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHX36→partner) and Y-score (partner→DHX36) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	PRLHR →	+0.030	+5.000	<.001	.005	3	1
KIDNEY	RGSL1 →	+0.043	+5.000	<.001	.005	3	1
KIDNEY	LMX1A →	+0.006	+5.000	<.001	.005	3	1
KIDNEY	WFDC12 →	+0.066	+5.000	<.001	.005	3	1
KIDNEY	TEX48 →	+0.133	+5.000	<.001	.005	3	1
OVARY	GAGE12H →	+0.292	+4.990	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 421 associations by consensus.

PRLHR by DHX36 expression — KIDNEY

Explore this box plot interactively →