DHX35

Across TCGA patient cohorts, DHX35 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DHX35-associated genes across cancer lineages are Caspase-7-cleavedD198, eIF4E, and ERK2. Each is linked with DHX35 in more than 2 cancer types. Because this analysis shows association rather than direction, both DHX35-to-partner and partner-to-DHX35 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by DHX35-low versus DHX35-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHX35→partner) and Y-score (partner→DHX35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.429	+2.827	.049	.001	3	3
UCEC	eIF4E →	+0.183	+3.335	.018	.005	3	2
UCEC	ERK2 →	+0.176	+2.700	.013	.006	3	2
UCEC	GSK-3a-b_pS21_S9 →	+0.384	+1.817	.014	.015	3	2
UCEC	N-Ras →	-0.109	-1.680	.012	.042	3	2
UCEC	Akt_pS473 →	+0.614	+1.502	.019	.030	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

Caspase-7-cleavedD198 by DHX35 expression — UCEC

Explore this box plot interactively →