DHX34

Across TCGA pan-cancer cohorts, DHX34 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DHX34 data layer compared with 29 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DHX34 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated DHX34 expression acts as an unfavorable survival marker, although some lineages such as LUAD and GBM show a favorable association.

HNSC, LUAD, and GBM are the cancer types where DHX34 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.606	0.907	.002	39	view →
LUAD	OS	Median	II,III,IV	0.866	0.491	.008	10	view →
GBM	OS	Quartile	All	0.646	0.323	.033	3	view →
LSCC	DFS	Median	II,III,IV	0.451	0.877	.044	1	view →
CCRCC	OS	Tertile	III,IV	0.341	0.743	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DHX34–HNSC (OS)

Open the HNSC breakdown →