DHX34

Across TCGA patient cohorts, DHX34 mutation is significantly associated with the RNA expression of many other genes, with 3,351 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DHX34-associated genes across cancer lineages are SFXN1, HASPIN, and UHRF1. Each is linked with DHX34 in more than 3 cancer types. Because this analysis shows association rather than direction, both DHX34-to-partner and partner-to-DHX34 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SFXN1 grouped by DHX34-low versus DHX34-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHX34→partner) and Y-score (partner→DHX34) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SFXN1 →	+0.470	+2.721	<.001	<.001	3	4
UCEC	HASPIN →	+0.570	+1.415	<.001	.002	3	4
UCEC	UHRF1 →	+0.553	+1.595	.001	<.001	3	4
UCEC	POLR3G →	+0.343	+1.447	<.001	.005	3	4
UCEC	CCDC89 →	-0.625	-1.765	<.001	<.001	3	4
UCEC	FANCA →	+0.459	+1.584	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,351 associations by consensus.

SFXN1 by DHX34 expression — UCEC

Explore this box plot interactively →