DHX34

Across TCGA cell cohorts, DHX34 mutation is significantly associated with the RNA expression of many other genes, with 320 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DHX34-associated genes across cancer lineages are IDI2, MAGEB5, and H4C7. Each is linked with DHX34 in more than 1 cancer types. Because this analysis shows association rather than direction, both DHX34-to-partner and partner-to-DHX34 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IDI2 grouped by DHX34-low versus DHX34-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHX34→partner) and Y-score (partner→DHX34) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	IDI2 →	+1.496	+4.491	.003	.002	3	2
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	H4C7 →	+0.389	+4.643	<.001	.008	3	1
BLOOD_Lymphoma	TECTB →	+0.063	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	C10orf53 →	+0.021	+4.867	.001	.009	3	1
LARGE_INTESTINE	CNIH1 →	+0.549	+3.451	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 320 associations by consensus.

IDI2 by DHX34 expression — KIDNEY

Explore this box plot interactively →