DHX33

Across TCGA patient cohorts, DHX33 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DHX33-associated genes across cancer lineages are ATM, eEF2, and EGFR_pY1068. Each is linked with DHX33 in more than 2 cancer types. Because this analysis shows association rather than direction, both DHX33-to-partner and partner-to-DHX33 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by DHX33-low versus DHX33-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHX33→partner) and Y-score (partner→DHX33) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.526	-2.502	.003	.002	3	3
UCEC	eEF2 →	+0.413	+2.000	.003	.030	3	2
UCEC	EGFR_pY1068 →	-0.222	-2.000	.024	.010	3	2
UCEC	mTOR_pS2448 →	-0.140	-1.986	.016	.029	3	2
UCEC	STAT3_pY705 →	-0.476	-2.405	<.001	.003	3	2
UCEC	eIF4E →	+0.220	+3.584	.007	.002	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

ATM by DHX33 expression — UCEC

Explore this box plot interactively →