DHX33

Across TCGA cell cohorts, DHX33 mutation is significantly associated with the RNA expression of many other genes, with 53 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible DHX33-associated genes across cancer lineages are PRAMEF15, PAX4, and CCL8. Each is linked with DHX33 in more than 1 cancer types. Because this analysis shows association rather than direction, both DHX33-to-partner and partner-to-DHX33 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF15 grouped by DHX33-low versus DHX33-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHX33→partner) and Y-score (partner→DHX33) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	PRAMEF15 →	+0.210	+5.357	<.001	.003	3	2
UPPER_AERODIGESTIVE_TRACT	PAX4 →	+0.029	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	CCL8 →	+0.006	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	PRAMEF2 →	+0.182	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	CNTN6 →	+0.036	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	CYLC2 →	+0.016	+5.357	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

PRAMEF15 by DHX33 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →