DHX32

Across TCGA patient cohorts, DHX32 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DHX32-associated genes across cancer lineages are eEF2, Mre11, and mTOR_pS2448. Each is linked with DHX32 in more than 1 cancer types. Because this analysis shows association rather than direction, both DHX32-to-partner and partner-to-DHX32 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by DHX32-low versus DHX32-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHX32→partner) and Y-score (partner→DHX32) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.324	+2.321	.013	.033	3	2
UCEC	Mre11 →	-0.072	-1.502	.022	.030	3	2
UCEC	mTOR_pS2448 →	-0.113	-1.980	.039	.030	3	2
UCEC	p62 Lck ligand →	+0.346	+3.817	.003	<.001	3	2
UCEC	Rictor_pT1135 →	-0.101	-1.700	.007	.042	3	2
UCEC	14-3-3_beta →	-0.089	-2.088	.016	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

eEF2 by DHX32 expression — UCEC

Explore this box plot interactively →