DHX32

Across TCGA cell cohorts, DHX32 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DHX32-associated genes across cancer lineages are OR51L1, HTR1A, and KCNK18. Each is linked with DHX32 in more than 1 cancer types. Because this analysis shows association rather than direction, both DHX32-to-partner and partner-to-DHX32 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR51L1 grouped by DHX32-low versus DHX32-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHX32→partner) and Y-score (partner→DHX32) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR51L1 →	+0.038	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	HTR1A →	+0.012	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	KCNK18 →	+0.014	+4.662	<.001	.005	3	1
LARGE_INTESTINE	TBC1D21 →	+0.015	+5.022	<.001	.002	3	1
LARGE_INTESTINE	PFN3 →	+0.169	+4.467	<.001	.004	3	1
LARGE_INTESTINE	IQCF6 →	+0.311	+4.467	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

OR51L1 by DHX32 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →