Across TCGA pan-cancer cohorts, DHX16 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated DHX16 data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher DHX16 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated DHX16 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

LSCC, UCEC, and LUAD are the cancer types where DHX16 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	All	0.901	0.625	.004	12	view →
UCEC	DFS	Median	All	0.795	0.921	.024	2	view →
LUAD	OS	Tertile	II,III,IV	1.000	0.514	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: DHX16 tumor-vs-normal RNA expression · all DHX16 data types