DHTKD1

Across TCGA pan-cancer cohorts, DHTKD1 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated DHTKD1 data layer compared with 21 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher DHTKD1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated DHTKD1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUSC show a favorable association.

OV, BLCA, and UCEC are the cancer types where DHTKD1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Median	II,III,IV	0.007	0.844	<.001	48	view →
BLCA	OS	Median	IV	0.078	0.598	<.001	24	view →
UCEC	DFS	Median	All	0.976	0.829	.023	12	view →
PCPG	DFS	Median	All	0.070	0.936	<.001	6	view →
SARC	DFS	Median	All	0.121	0.611	.041	6	view →
LGG	DFS	Median	All	0.110	0.833	<.001	6	view →
SCLC	OS	Median	II,III,IV	0.152	0.777	.038	3	view →
LUSC	DFS	Median	All	1.000	0.385	.033	2	view →
COAD	DFS	Median	All	1.000	0.679	.034	2	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

DHTKD1–OV (OS)

Open the OV breakdown →