DHTKD1

Across TCGA pan-cancer cohorts, DHTKD1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated DHTKD1 data layer compared with 21 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher DHTKD1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated DHTKD1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

PDAC, HNSC, and CCRCC are the cancer types where DHTKD1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	II,III,IV	0.465	0.283	.006	27	view →
HNSC	DFS	Tertile	III,IV	1.000	0.302	.011	20	view →
CCRCC	DFS	Quartile	All	0.982	0.426	.009	19	view →
GBM	DFS	Tertile	All	0.872	0.675	.008	12	view →
UCEC	DFS	Tertile	III,IV	0.491	1.000	.025	8	view →
LUAD	DFS	Median	All	0.910	0.673	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

DHTKD1–PDAC (DFS)

Open the PDAC breakdown →