DHTKD1

Across TCGA patient cohorts, DHTKD1 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DHTKD1-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and Cyclin-E1. Each is linked with DHTKD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both DHTKD1-to-partner and partner-to-DHTKD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by DHTKD1-low versus DHTKD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHTKD1→partner) and Y-score (partner→DHTKD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.574	-2.321	<.001	.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.598	+2.135	.005	.010	3	3
BLCA	Cyclin-E1 →	+0.450	+3.169	.010	.019	3	2
UCEC	cIAP →	+0.098	+2.125	.046	.010	3	2
UCEC	c-Kit →	-0.184	-1.925	.028	.005	3	2
BLCA	Shc_pY317 →	+0.198	+3.187	.045	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

ATM by DHTKD1 expression — UCEC

Explore this box plot interactively →