DHTKD1

Across TCGA cell cohorts, DHTKD1 mutation is significantly associated with the RNA expression of many other genes, with 31 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible DHTKD1-associated genes across cancer lineages are TOPAZ1, BTBD16, and NKX6-1. Each is linked with DHTKD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DHTKD1-to-partner and partner-to-DHTKD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TOPAZ1 grouped by DHTKD1-low versus DHTKD1-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHTKD1→partner) and Y-score (partner→DHTKD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TOPAZ1 →	+0.022	+4.285	<.001	.007	3	2
BLOOD_Leukemia	BTBD16 →	+0.081	+3.959	<.001	.005	3	1
BLOOD_Leukemia	NKX6-1 →	+0.599	+3.536	.002	.008	3	1
BLOOD_Leukemia	KIR3DL1 →	+0.023	+3.691	.002	.002	3	1
BLOOD_Leukemia	TACR3 →	+0.030	+4.475	<.001	<.001	3	1
BLOOD_Leukemia	PRND →	+0.007	+3.289	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

TOPAZ1 by DHTKD1 expression — STOMACH

Explore this box plot interactively →