DHRSX

Across TCGA patient cohorts, DHRSX mutation is significantly associated with the RNA expression of many other genes, with 1,525 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DHRSX-associated genes across cancer lineages are CYP51A1, RNU6-1085P, and RNU6-328P. Each is linked with DHRSX in more than 1 cancer types. Because this analysis shows association rather than direction, both DHRSX-to-partner and partner-to-DHRSX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CYP51A1 grouped by DHRSX-low versus DHRSX-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHRSX→partner) and Y-score (partner→DHRSX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CYP51A1 →	+0.787	+3.338	<.001	.005	3	2
BLCA	RNU6-1085P →	+0.376	+4.973	.001	.009	3	2
BLCA	RNU6-328P →	+0.299	+6.618	.002	.001	3	2
LUAD	OR5AC1 →	+0.115	+5.984	<.001	.002	3	2
UCEC	NF1P10 →	+0.137	+2.345	.005	.007	3	2
UCEC	FLVCR1-DT →	+0.594	+3.711	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,525 associations by consensus.

CYP51A1 by DHRSX expression — UCEC

Explore this box plot interactively →