DHRSX

Across TCGA patient cohorts, DHRSX mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DHRSX-associated genes across cancer lineages are 53BP1, FoxM1, and IRS1. Each is linked with DHRSX in more than 1 cancer types. Because this analysis shows association rather than direction, both DHRSX-to-partner and partner-to-DHRSX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 53BP1 grouped by DHRSX-low versus DHRSX-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHRSX→partner) and Y-score (partner→DHRSX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	53BP1 →	+0.494	+2.999	.003	.035	3	2
UCEC	FoxM1 →	+0.336	+3.459	.009	.005	3	1
UCEC	IRS1 →	+0.228	+2.321	.028	.035	3	1
UCEC	Ku80 →	+0.349	+2.820	.003	.035	3	1
UCEC	PCNA →	+0.324	+2.321	.002	.035	3	1
UCEC	Annexin-1 →	+0.678	+2.827	.010	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

53BP1 by DHRSX expression — UCEC

Explore this box plot interactively →