Across TCGA pan-cancer cohorts, DHRS7C Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DHRS7C data layer compared with 21 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher DHRS7C Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated DHRS7C expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, PRAD, and LIHC are the cancer types where DHRS7C Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	1.000	0.438	.016	22	view →
PRAD	OS	Median	All	0.540	0.990	<.001	12	view →
LIHC	DFS	Median	All	0.044	0.553	<.001	12	view →
STAD	OS	Median	All	0.100	0.539	.009	12	view →
SKCM	OS	Median	IV	0.179	0.755	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: DHRS7C tumor-vs-normal RNA expression · all DHRS7C data types