Across TCGA patient cohorts, DHRS4L2 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DHRS4L2-associated genes across cancer lineages are EGFR_pY1068, Shc_pY317, and Src_pY527. Each is linked with DHRS4L2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DHRS4L2-to-partner and partner-to-DHRS4L2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHRS4L2→partner) and Y-score (partner→DHRS4L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.371	-3.000	.010	.037	3	1
UCEC	Shc_pY317 →	-0.288	-3.000	.001	.037	3	1
UCEC	Src_pY527 →	-0.710	-3.000	.004	.037	3	1
UCEC	4E-BP1_pT70 →	+0.217	+3.000	.001	.037	3	1
UCEC	Cyclin-B1 →	+0.847	+3.000	.008	.037	1	1
UCEC	Di-Ras3 →	-0.219	-3.000	.010	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

DHRS4L2 survival (RNA) · tumor vs normal (RNA) · all DHRS4L2 data types