Across TCGA pan-cancer cohorts, DHRS4L1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of DHRS4L1’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where DHRS4L1 RNA is repressed in tumor relative to normal tissue. In most cancer types DHRS4L1 is over-expressed in tumor, although a few such as THCA and CHOL show the opposite, repressed pattern.
THCA, CHOL, and KIRP are the cancer types where DHRS4L1 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DHRS4L1 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.