DHRS4

Across TCGA pan-cancer cohorts, DHRS4 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated DHRS4 data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher DHRS4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated DHRS4 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

LUAD, GBM, and UCEC are the cancer types where DHRS4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	III,IV	0.322	0.690	.001	40	view →
GBM	OS	Quartile	All	0.253	0.531	.006	13	view →
UCEC	OS	Quartile	II,III,IV	0.338	1.000	.022	12	view →
CCRCC	OS	Tertile	All	1.000	0.858	.009	10	view →
PDAC	OS	Tertile	All	0.466	0.298	.014	10	view →
HNSC	OS	Median	IV	0.645	0.831	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

DHRS4–LUAD (DFS)

Open the LUAD breakdown →