DHRS4

Across TCGA patient cohorts, DHRS4 mutation is significantly associated with the RNA expression of many other genes, with 447 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DHRS4-associated genes across cancer lineages are VTRNA2-2P, CDRT15P5, and RNA5SP281. Each is linked with DHRS4 in more than 1 cancer types. Because this analysis shows association rather than direction, both DHRS4-to-partner and partner-to-DHRS4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VTRNA2-2P grouped by DHRS4-low versus DHRS4-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHRS4→partner) and Y-score (partner→DHRS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	VTRNA2-2P →	+0.397	+4.601	<.001	.004	3	2
BLCA	CDRT15P5 →	+0.066	+5.147	<.001	.003	3	2
BLCA	RNA5SP281 →	+0.255	+5.289	<.001	.003	3	2
COAD	AP1B1P2 →	+0.453	+5.602	.001	.004	3	1
COAD	MTATP6P20 →	+0.162	+5.212	.004	.007	3	1
COAD	TRAV15 →	+0.334	+5.790	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 447 associations by consensus.

VTRNA2-2P by DHRS4 expression — CESC

Explore this box plot interactively →