DHRS4

Across TCGA patient cohorts, DHRS4 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DHRS4-associated genes across cancer lineages are VHL, EGFR_pY1068, and FOXO3a. Each is linked with DHRS4 in more than 1 cancer types. Because this analysis shows association rather than direction, both DHRS4-to-partner and partner-to-DHRS4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by DHRS4-low versus DHRS4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHRS4→partner) and Y-score (partner→DHRS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-0.869	-3.000	.019	.036	3	2
UCEC	EGFR_pY1068 →	-0.317	-3.169	.021	.020	3	1
UCEC	FOXO3a →	-0.109	-2.970	.049	.036	3	1
UCEC	JNK_pT183_Y185 →	-0.190	-3.156	.039	.020	3	1
UCEC	p62 Lck ligand →	+0.723	+3.009	<.001	.019	3	1
UCEC	Tuberin →	+0.327	+3.169	.027	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

VHL by DHRS4 expression — UCEC

Explore this box plot interactively →