DHRS4

Across TCGA cell cohorts, DHRS4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,495 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible DHRS4-associated GO terms across cancer lineages are Protein linear polyubiquitination, Retinal metabolic process, and Aldehyde metabolic process. Each is linked with DHRS4 in more than 13 cancer types. Because this analysis shows association rather than direction, both DHRS4-to-partner and partner-to-DHRS4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein linear polyubiquitination grouped by DHRS4-low versus DHRS4-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DHRS4→partner) and Y-score (partner→DHRS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Protein linear polyubiquitination →	+0.143	+1.351	<.001	.002	3	14
BLOOD_Lymphoma	Retinal metabolic process →	+0.156	+1.208	<.001	<.001	3	10
BLOOD_Lymphoma	Aldehyde metabolic process →	+0.102	+0.970	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.117	+0.745	.001	.004	3	9
UPPER_AERODIGESTIVE_TRACT	Negative regulation of mRNA processing →	+0.098	+0.884	.003	.007	3	8
BONE	Lysosome organization →	+0.056	+1.136	.001	.008	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,495 associations by consensus.

Protein linear polyubiquitination by DHRS4 expression — BONE

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