DHRS3

Across TCGA patient cohorts, DHRS3 mutation is significantly associated with the immune_cell of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DHRS3-associated genes across cancer lineages are Epithelial cells, lymphatic Endothelial cells, and Mesangial cells. Each is linked with DHRS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both DHRS3-to-partner and partner-to-DHRS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Epithelial cells grouped by DHRS3-low versus DHRS3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHRS3→partner) and Y-score (partner→DHRS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Epithelial cells →	-0.107	-2.584	.001	.011	3	1
UCEC	lymphatic Endothelial cells →	-0.024	-2.281	.031	.035	3	1
UCEC	Mesangial cells →	-0.053	-3.258	.003	.010	3	1
UCEC	mv Endothelial cells →	-0.022	-2.947	.041	.036	3	1
UCEC	pDC →	+0.079	+1.885	<.001	.032	3	1
UCEC	Th2 cells →	+0.232	+3.010	.005	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Epithelial cells by DHRS3 expression — UCEC

Explore this box plot interactively →