DHRS1

Across TCGA pan-cancer cohorts, DHRS1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DHRS1 data layer compared with 22 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher DHRS1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated DHRS1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

CCRCC, HNSC, and LSCC are the cancer types where DHRS1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.919	0.548	.007	35	view →
HNSC	OS	Quartile	All	0.945	0.771	.030	14	view →
LSCC	DFS	Quartile	All	0.851	1.000	.007	10	view →
PDAC	OS	Median	III,IV	0.755	0.404	.032	4	view →
LUAD	DFS	Quartile	II,III,IV	0.376	0.811	.028	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DHRS1–CCRCC (DFS)

Open the CCRCC breakdown →