DHPS

Across TCGA pan-cancer cohorts, DHPS mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated DHPS data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher DHPS mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated DHPS expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

LSCC, CCRCC, and GBM are the cancer types where DHPS mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	II,III,IV	0.993	0.666	<.001	27	view →
CCRCC	OS	Tertile	III,IV	0.470	0.870	.003	14	view →
GBM	OS	Median	All	0.540	0.273	.023	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

DHPS–LSCC (OS)

Open the LSCC breakdown →