DHPS

Across TCGA pan-cancer cohorts, DHPS mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of DHPS’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where DHPS mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types DHPS is over-expressed in tumor.

HNSC, LSCC, and CCRCC are the cancer types where DHPS tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DHPS mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	All	+0.807	<.001	11	view →
LSCC	Male	III,IV	+0.618	<.001	7	view →
CCRCC	All	All	+0.165	<.001	7	view →
PDAC	All	All	+0.483	<.001	6	view →
LUAD	Male	II,III,IV	+0.238	<.001	6	view →
COAD	All	All	+0.194	.009	3	view →
OV	All	All	+0.614	.020	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

DHPS–HNSC

Open the HNSC breakdown →