DHPS

Across TCGA patient cohorts, DHPS protein abundance is significantly associated with the RNA expression of many other genes, with 13,274 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DHPS-associated genes across cancer lineages are ASF1B, KIF15, and POC1A. Each is linked with DHPS in more than 6 cancer types. Because this analysis shows association rather than direction, both DHPS-to-partner and partner-to-DHPS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DHPS versus ASF1B in LSCC, with a Pearson correlation of 0.45.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHPS→partner) and Y-score (partner→DHPS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ASF1B →	+0.971	+0.488	<.001	<.001	3	7
GBM	KIF15 →	+1.094	+0.468	<.001	<.001	3	7
UCEC	POC1A →	+0.741	+0.320	.001	<.001	3	7
BRCA	CCNA2 →	+0.886	+0.412	.001	.003	3	7
BRCA	SGO1 →	+0.760	+0.479	<.001	<.001	3	6
GBM	BRIP1 →	+0.909	+0.343	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,274 associations by consensus.

DHPS vs ASF1B — LSCC

Explore this scatter interactively →