DHPS

Across TCGA patient cohorts, DHPS mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DHPS-associated genes across cancer lineages are HER3, PDCD4, and Bax. Each is linked with DHPS in more than 1 cancer types. Because this analysis shows association rather than direction, both DHPS-to-partner and partner-to-DHPS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HER3 grouped by DHPS-low versus DHPS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHPS→partner) and Y-score (partner→DHPS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HER3 →	+0.214	+2.820	.047	.035	3	2
UCEC	PDCD4 →	-0.603	-2.690	.001	.006	3	2
UCEC	Bax →	+0.216	+1.584	.022	.036	3	2
UCEC	C-Raf →	+0.212	+2.321	<.001	.033	3	2
UCEC	eIF4E →	+0.182	+3.584	.028	.002	3	1
UCEC	A-Raf_pS299 →	-0.128	-2.459	.006	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

HER3 by DHPS expression — UCEC

Explore this box plot interactively →