DHPS

Across TCGA cell cohorts, DHPS RNA expression is significantly associated with the go_rna of many other GO terms, with 3,368 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DHPS-associated GO terms across cancer lineages are Negative regulation of protein localization to chromatin, mRNA cis splicing, via spliceosome, and Subtelomeric heterochromatin formation. Each is linked with DHPS in more than 13 cancer types. Because this analysis shows association rather than direction, both DHPS-to-partner and partner-to-DHPS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of protein localization to chromatin grouped by DHPS-low versus DHPS-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DHPS→partner) and Y-score (partner→DHPS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of protein localization to chromatin →	+0.169	+0.719	<.001	.005	3	14
PANCREAS	mRNA cis splicing, via spliceosome →	+0.090	+0.690	<.001	<.001	3	14
BONE	Subtelomeric heterochromatin formation →	+0.170	+0.895	<.001	<.001	3	13
BONE	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.228	+0.799	.003	.001	3	12
BONE	Positive regulation of anaphase-promoting complex-dependent catabolic process →	+0.198	+0.855	.001	.001	3	12
LARGE_INTESTINE	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.158	+0.533	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,368 associations by consensus.

Negative regulation of protein localization to chromatin by DHPS expression — BONE

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