DHODH

Across TCGA pan-cancer cohorts, DHODH Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DHODH data layer compared with 24 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher DHODH Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated DHODH expression acts as an unfavorable survival marker, although some lineages such as COAD show a favorable association.

ACC, ESCA, and LUSC are the cancer types where DHODH Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.046	0.753	<.001	36	view →
ESCA	OS	Median	II,III,IV	0.216	0.702	.014	6	view →
LUSC	DFS	Median	All	0.136	0.758	.002	6	view →
LIHC	OS	Median	All	0.247	0.690	.017	6	view →
COAD	DFS	Median	All	1.000	0.459	.046	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DHODH–ACC (DFS)

Open the ACC breakdown →