DHH

Across TCGA patient cohorts, DHH mutation is significantly associated with the RNA expression of many other genes, with 206 significant associations in total. COAD shows the largest number of these associations.

The most reproducible DHH-associated genes across cancer lineages are TXNL4AP1, RPL30P13, and MTCO3P10. Each is linked with DHH in more than 1 cancer types. Because this analysis shows association rather than direction, both DHH-to-partner and partner-to-DHH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TXNL4AP1 grouped by DHH-low versus DHH-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHH→partner) and Y-score (partner→DHH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TXNL4AP1 →	+0.279	+3.781	<.001	.001	3	2
COAD	RPL30P13 →	+0.371	+3.342	.009	.004	3	2
COAD	MTCO3P10 →	+0.228	+3.321	<.001	.008	3	2
COAD	BRWD1P3 →	+0.309	+4.278	<.001	.001	3	2
UCEC	IGHD2-2 →	+1.371	+2.872	.008	.002	3	2
UCEC	RNU7-110P →	+0.838	+4.509	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 206 associations by consensus.

TXNL4AP1 by DHH expression — COAD

Explore this box plot interactively →