DHH

Across TCGA patient cohorts, DHH mutation is significantly associated with the total protein of many other genes, with 2 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DHH-associated genes across cancer lineages are Ku80 and VEGFR2. Each is linked with DHH in more than 1 cancer types. Because this analysis shows association rather than direction, both DHH-to-partner and partner-to-DHH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by DHH-low versus DHH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHH→partner) and Y-score (partner→DHH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.347	+2.820	.016	.036	3	1
UCEC	VEGFR2 →	+0.463	+2.820	.010	.036	1	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

Ku80 by DHH expression — UCEC

Explore this box plot interactively →