DHH

Across TCGA cell cohorts, DHH mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DHH-associated genes across cancer lineages are C6orf118, MOG, and OR2V1. Each is linked with DHH in more than 1 cancer types. Because this analysis shows association rather than direction, both DHH-to-partner and partner-to-DHH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C6orf118 grouped by DHH-low versus DHH-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHH→partner) and Y-score (partner→DHH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C6orf118 →	+0.113	+3.378	<.001	.001	3	1
LARGE_INTESTINE	MOG →	+0.087	+2.791	.003	.005	3	1
STOMACH	OR2V1 →	+0.070	+4.129	.002	.007	3	1
STOMACH	SSX7 →	+0.325	+4.285	<.001	.007	3	1
STOMACH	USP17L17 →	+0.010	+4.285	<.001	.007	3	1
BLOOD_Lymphoma	GRXCR1 →	+0.019	+5.643	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

C6orf118 by DHH expression — LARGE_INTESTINE

Explore this box plot interactively →