DHFRP3

Across TCGA pan-cancer cohorts, DHFRP3 RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated DHFRP3 data layer.

The strongest signal is observed in testicular germ cell tumors (TGCT), where higher DHFRP3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DHFRP3 expression acts as an unfavorable survival marker.

TGCT, DLBC, and BRCA are the cancer types where DHFRP3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
TGCT	DFS	Tertile	III,IV	0.340	1.000	.002	66	view →
DLBC	OS	Tertile	III,IV	0.175	0.874	.025	36	view →
BRCA	OS	Tertile	All	0.464	0.584	.020	30	view →
BLCA	DFS	Tertile	IV	0.140	0.471	.022	27	view →
PAAD	DFS	Tertile	II,III,IV	0.192	0.441	.022	27	view →
COAD	DFS	Tertile	II,III,IV	0.310	0.659	.010	18	view →
SARC	OS	Tertile	All	0.085	0.827	<.001	18	view →
LUAD	OS	Tertile	All	0.620	0.841	.028	12	view →
UCEC	OS	Tertile	All	0.226	0.691	.013	12	view →
STAD	OS	Quartile	III,IV	0.354	0.683	<.001	9	view →
LGG	DFS	Tertile	All	0.384	0.851	<.001	9	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

DHFRP3–TGCT (DFS)

Open the TGCT breakdown →