DHFR2

Across TCGA patient cohorts, DHFR2 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,413 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DHFR2-associated proteins across cancer lineages are CKAP4_S26, TLR2, and ADH5. Each is linked with DHFR2 in more than 4 cancer types. Because this analysis shows association rather than direction, both DHFR2-to-partner and partner-to-DHFR2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DHFR2 versus CKAP4_S26 in UCEC, with a Pearson correlation of -0.32.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DHFR2→partner) and Y-score (partner→DHFR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CKAP4_S26 →	-0.706	-0.425	.001	.004	3	5
BRCA	TLR2 →	-0.425	-0.411	<.001	<.001	3	5
UCEC	ADH5 →	+0.293	+0.381	<.001	<.001	3	5
GBM	DOK3 →	-0.545	-0.444	<.001	<.001	3	5
GBM	ARL6 →	+0.242	+0.355	.006	.008	3	4
BRCA	YARS1 →	-0.303	-0.677	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,413 associations by consensus.

DHFR2 vs CKAP4_S26 — UCEC

Explore this scatter interactively →