DHFR2

Across TCGA cell cohorts, DHFR2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,296 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DHFR2-associated GO terms across cancer lineages are Thymidine biosynthetic process, 2'-deoxyribonucleoside biosynthetic process, and Pyrimidine deoxyribonucleoside biosynthetic process. Each is linked with DHFR2 in more than 15 cancer types. Because this analysis shows association rather than direction, both DHFR2-to-partner and partner-to-DHFR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Thymidine biosynthetic process grouped by DHFR2-low versus DHFR2-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DHFR2→partner) and Y-score (partner→DHFR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Thymidine biosynthetic process →	-0.249	-0.912	<.001	<.001	3	16
STOMACH	2'-deoxyribonucleoside biosynthetic process →	-0.249	-0.912	<.001	<.001	3	16
STOMACH	Pyrimidine deoxyribonucleoside biosynthetic process →	-0.249	-0.912	<.001	<.001	3	16
LUNG_SCLC	Protein localization to chromosome, telomeric region →	+0.109	+0.686	<.001	<.001	3	12
OESOPHAGUS	Transport along microtubule →	+0.055	+0.701	<.001	.001	3	10
CNS	Cytoskeleton-dependent intracellular transport →	+0.029	+0.449	.002	.002	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,296 associations by consensus.

Thymidine biosynthetic process by DHFR2 expression — STOMACH

Explore this box plot interactively →