Across TCGA patient cohorts, DHFR mutation is significantly associated with the RNA expression of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DHFR-associated genes across cancer lineages are LINC02165, MIR8076, and RNA5SP27. Each is linked with DHFR in more than 1 cancer types. Because this analysis shows association rather than direction, both DHFR-to-partner and partner-to-DHFR results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHFR→partner) and Y-score (partner→DHFR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	LINC02165 →	+0.064	+7.930	<.001	.008	3	2
SKCM	MIR8076 →	+0.499	+5.436	<.001	.005	3	1
PRAD	RNA5SP27 →	+0.678	+7.939	<.001	.008	3	1
PRAD	RNU5E-7P →	+0.308	+7.939	<.001	.008	3	1
PRAD	H2ACP1 →	+0.209	+7.939	<.001	.008	3	1
PRAD	MTCO1P44 →	+0.509	+7.939	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Exploration

DHFR survival (RNA) · tumor vs normal (RNA) · all DHFR data types