DHFR

mutation — cross-omics
Cross-omicsMUTATION → IMMUNEPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, DHFR mutation is significantly associated with the immune_cell of many other genes, with 2 significant associations in total. PRAD shows the largest number of these associations.

The most reproducible DHFR-associated genes across cancer lineages are CD4+ Tem and Adipocytes. Each is linked with DHFR in more than 1 cancer types. Because this analysis shows association rather than direction, both DHFR-to-partner and partner-to-DHFR results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHFR→partner) and Y-score (partner→DHFR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
PRADCD4+ Tem →+0.024+5.593<.001.04031
UCECAdipocytes →+0.027+2.851.031.04431
Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

Exploration