Across TCGA cell cohorts, DHFR RNA expression is significantly associated with the go_rna of many other GO terms, with 4,903 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible DHFR-associated GO terms across cancer lineages are DNA replication initiation, Mitotic DNA replication checkpoint signaling, and Dihydrofolate metabolic process. Each is linked with DHFR in more than 19 cancer types. Because this analysis shows association rather than direction, both DHFR-to-partner and partner-to-DHFR results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DHFR→partner) and Y-score (partner→DHFR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	DNA replication initiation →	+0.169	+1.382	<.001	<.001	3	20
PANCREAS	Mitotic DNA replication checkpoint signaling →	+0.156	+0.988	<.001	<.001	3	20
LIVER	Dihydrofolate metabolic process →	+0.272	+1.704	<.001	<.001	3	20
OESOPHAGUS	Positive regulation of chromosome condensation →	+0.278	+1.418	<.001	<.001	3	19
OESOPHAGUS	DNA replication →	+0.108	+0.990	.001	.004	3	18
OESOPHAGUS	DNA-templated DNA replication →	+0.116	+1.113	.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,903 associations by consensus.

Exploration

DHFR survival (RNA) · tumor vs normal (RNA) · all DHFR data types