DHDH

Across TCGA patient cohorts, DHDH protein abundance is significantly associated with the RNA expression of many other genes, with 12,468 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible DHDH-associated genes across cancer lineages are PSME2, SAMHD1, and IRF1. Each is linked with DHDH in more than 6 cancer types. Because this analysis shows association rather than direction, both DHDH-to-partner and partner-to-DHDH results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DHDH versus PSME2 in HNSC, with a Pearson correlation of 0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHDH→partner) and Y-score (partner→DHDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PSME2 →	+0.983	+0.565	<.001	<.001	3	7
HNSC	SAMHD1 →	+1.096	+0.881	<.001	<.001	3	7
HNSC	IRF1 →	+1.078	+0.832	<.001	<.001	3	7
HNSC	GBP5 →	+1.808	+0.773	<.001	<.001	3	7
HNSC	TAP1 →	+1.204	+0.786	<.001	<.001	3	7
HNSC	SCO2 →	+0.621	+0.420	.004	.006	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,468 associations by consensus.

DHDH vs PSME2 — HNSC

Explore this scatter interactively →