DHDH

Across TCGA patient cohorts, DHDH mutation is significantly associated with the RNA expression of many other genes, with 1,203 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DHDH-associated genes across cancer lineages are PRSS53, DAPK3, and RNU6ATAC30P. Each is linked with DHDH in more than 1 cancer types. Because this analysis shows association rather than direction, both DHDH-to-partner and partner-to-DHDH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRSS53 grouped by DHDH-low versus DHDH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHDH→partner) and Y-score (partner→DHDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRSS53 →	+0.285	+3.162	.001	<.001	3	2
UCEC	DAPK3 →	+0.425	+4.202	.006	<.001	3	2
COAD	RNU6ATAC30P →	+0.300	+4.308	.007	.009	3	2
UCEC	AOC2 →	+1.287	+1.928	<.001	.009	3	2
UCEC	NARF →	+0.355	+2.425	.007	.002	3	2
UCEC	BOLA3P3 →	+0.283	+2.069	.005	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,203 associations by consensus.

PRSS53 by DHDH expression — UCEC

Explore this box plot interactively →