DHDH

Across TCGA patient cohorts, DHDH mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DHDH-associated genes across cancer lineages are JNK_pT183_Y185, Ku80, and MAPK_pT202_Y204. Each is linked with DHDH in more than 1 cancer types. Because this analysis shows association rather than direction, both DHDH-to-partner and partner-to-DHDH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by DHDH-low versus DHDH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHDH→partner) and Y-score (partner→DHDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.212	-2.321	.006	.034	3	1
UCEC	Ku80 →	+0.289	+1.887	.008	.031	3	1
UCEC	MAPK_pT202_Y204 →	-0.564	-2.459	.010	.019	3	1
UCEC	MEK1 →	+0.430	+2.584	.011	.011	3	1
UCEC	Notch1 →	+0.141	+2.183	.031	.033	3	1
UCEC	Annexin-1 →	+0.671	+3.189	.006	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

JNK_pT183_Y185 by DHDH expression — UCEC

Explore this box plot interactively →