DHDH

Across TCGA cell cohorts, DHDH RNA expression is significantly associated with the go_rna of many other GO terms, with 3,044 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DHDH-associated GO terms across cancer lineages are Pentose catabolic process, D-xylose metabolic process, and Establishment of epithelial cell apical/basal polarity. Each is linked with DHDH in more than 18 cancer types. Because this analysis shows association rather than direction, both DHDH-to-partner and partner-to-DHDH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Pentose catabolic process grouped by DHDH-low versus DHDH-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DHDH→partner) and Y-score (partner→DHDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Pentose catabolic process →	-0.253	-0.850	<.001	<.001	3	19
OVARY	D-xylose metabolic process →	-0.223	-0.869	<.001	<.001	3	15
STOMACH	Establishment of epithelial cell apical/basal polarity →	-0.186	-1.086	.003	.001	3	10
OVARY	Regulation of myoblast fusion →	+0.107	+0.875	<.001	.001	3	10
OVARY	Regulation of syncytium formation by plasma membrane fusion →	+0.106	+0.845	<.001	.001	2	10
OVARY	Cytoplasmic translation →	+0.073	+0.632	.002	.004	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,044 associations by consensus.

Pentose catabolic process by DHDH expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →