DHDDS

Across TCGA pan-cancer cohorts, DHDDS mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DHDDS data layer compared with 20 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher DHDDS mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated DHDDS expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

PDAC, LUAD, and CCRCC are the cancer types where DHDDS mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	II,III,IV	0.736	0.233	.004	33	view →
LUAD	OS	Quartile	II,III,IV	1.000	0.311	.005	12	view →
CCRCC	OS	Median	II,III,IV	0.561	0.877	.009	3	view →
LSCC	OS	Median	II,III,IV	1.000	0.908	.049	1	view →
HNSC	OS	Median	All	0.956	1.000	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DHDDS–PDAC (DFS)

Open the PDAC breakdown →