DHDDS

Across TCGA patient cohorts, DHDDS RNA expression is significantly associated with the mutation status of many other genes, with 10,880 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DHDDS-associated genes across cancer lineages are TP53, TTN, and FLG2. Each is linked with DHDDS in more than 7 cancer types. Because this analysis shows association rather than direction, both DHDDS-to-partner and partner-to-DHDDS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TP53 grouped by DHDDS-low versus DHDDS-high in LIHC.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHDDS→partner) and Y-score (partner→DHDDS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	TP53 →	+1.847	+0.474	<.001	<.001	3	8
UCEC	TTN →	+0.612	+0.153	<.001	<.001	3	5
COAD	FLG2 →	+3.222	+0.289	.008	.006	3	5
UCEC	DNAH8 →	+1.117	+0.259	<.001	<.001	3	5
UCEC	DGKK →	+1.625	+0.354	<.001	<.001	3	5
COAD	FLNC →	+2.637	+0.250	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,880 associations by consensus.

TP53 by DHDDS expression — LIHC

Explore this box plot interactively →