DHDDS

Across TCGA patient cohorts, DHDDS protein abundance is significantly associated with the RNA expression of many other genes, with 6,478 significant associations in total. GBM shows the largest number of these associations.

The most reproducible DHDDS-associated genes across cancer lineages are AQP9, IGIP, and GAB1. Each is linked with DHDDS in more than 4 cancer types. Because this analysis shows association rather than direction, both DHDDS-to-partner and partner-to-DHDDS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DHDDS versus AQP9 in PDAC, with a Pearson correlation of 0.69.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHDDS→partner) and Y-score (partner→DHDDS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	AQP9 →	+2.035	+0.654	.007	.005	3	5
PDAC	IGIP →	-0.692	-0.654	.002	.008	3	5
PDAC	GAB1 →	-0.685	-0.647	.006	.009	3	3
LUAD	CDC20 →	+1.311	+0.310	<.001	<.001	3	3
PDAC	PLXDC2 →	-0.745	-0.692	<.001	.006	3	3
PDAC	G0S2 →	+1.554	+0.607	.006	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,478 associations by consensus.

DHDDS vs AQP9 — PDAC

Explore this scatter interactively →